Rheumatoid arthritis (RA) is a complex condition where both genetics and environmental factors play a significant role. It’s not considered an inherited disorder in the traditional sense, but certain genes may increase the risk of developing RA. This autoimmune disorder likely results from a combination of genetic predispositions and unknown environmental factors.
Research indicates that RA is a multigene disorder with a substantial genetic component. Studies, including large-scale Genome-Wide Association Studies (GWAS), have identified common disease-associated variants that may contribute cumulatively to RA pathogenesis. The estimated heritability of RA is around 60%, highlighting the significant role genetics play.
Moreover, RA tends to cluster in families, suggesting a hereditary aspect. Understanding the role that genetics and heredity play in RA can enhance the likelihood of early detection and effective management. Factors like age, sex, smoking, and obesity are also known risk factors for RA.
In addition to genetic predispositions, acquired immune response factors, including gene-gene and gene-environment interactions, are crucial in the risk of rheumatoid arthritis. The complex interplay between genetics, environment, and autoimmunity forms what is sometimes referred to as the “Bermuda triangle” in the pathogenesis of RA.
For more detailed information, you can refer to the following sources:
Healthline
National Center for Biotechnology Information
MedlinePlus Genetics
Pfizer
Rheumatology | Oxford Academic
PMC – National Center for Biotechnology Information
National Center for Biotechnology Information
