A positive rheumatoid factor test result indicates a high level of rheumatoid factor in the blood, closely associated with autoimmune diseases, especially rheumatoid arthritis. However, several other diseases and conditions, including cancer, can also elevate rheumatoid factor levels. What does it mean to have a positive rheumatoid factor (RF)? Does this indicate rheumatoid arthritis, a risk of developing it, a worse prognosis, or is it unrelated to arthritis?
Rheumatoid factor (RF) is an immune system protein that sometimes attacks healthy cells and tissues. Normally, the immune system produces antibodies to fight germs, but rheumatoid factors are antibodies that can mistakenly target healthy tissues. A high level of RF (a positive rheumatoid factor test) is often linked to more severe rheumatoid disease and a higher likelihood of non-joint manifestations like rheumatoid nodules and lung disease.
Contrary to its name, rheumatoid factors (RF) are found not only in rheumatoid arthritis (RA) but in various pathologies, including other autoimmune and non-autoimmune diseases. They can even be present in up to 4% of young, healthy individuals and are more common in the elderly. StatPearls – NCBI Bookshelf
The RF test helps distinguish RA from other types of arthritis, like osteoarthritis or psoriatic arthritis, and may rule out other conditions with similar symptoms. Symptoms such as fever and weight loss can also guide the diagnosis. Verywell Health
For a comprehensive understanding of rheumatoid factor, its normal range, and its implications in diagnosing and managing rheumatoid arthritis, visit Mayo Clinic, RheumDoctor, Medical News Today, RheumatoidArthritis.org, and MedicineNet for detailed information.
