Rheumatoid factor (RF) is a significant autoantibody primarily associated with rheumatoid arthritis (RA). This antibody targets the Fc portion of IgG and can manifest in any immunoglobulin isotype. The presence of rheumatoid factor in the blood is a common indicator in many patients with rheumatoid arthritis, and its measurement is crucial in diagnosing and monitoring the disease.
A rheumatoid factor test, a part of a group of blood tests, plays a vital role in diagnosing rheumatoid arthritis. This test measures the level of rheumatoid factor in a patient’s blood. A positive rheumatoid factor test indicates a high level of this factor in the blood. Alongside the RF test, other tests such as Anti-nuclear antibody (ANA), Anti-cyclic citrullinated peptide (anti-CCP) antibodies, C-reactive protein (CRP), and Erythrocyte sedimentation rate (ESR or sed rate) are also used to confirm a diagnosis of rheumatoid arthritis.
RF is the autoantibody initially discovered in the context of rheumatoid arthritis. It is noteworthy that RF can also be present in individuals without rheumatoid arthritis, including healthy individuals and those with other autoimmune diseases. The test for rheumatoid factor is an essential tool for healthcare professionals in diagnosing rheumatoid arthritis, as it is detectable in about 80% of adults with the condition. However, it is important to note that high RF levels can also indicate other autoimmune diseases.
Rheumatoid Arthritis
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