Biologics are a newer class of DMARDs (Disease-Modifying Anti-Rheumatic Drugs) that have significantly improved treatment outcomes for individuals with Rheumatoid Arthritis (RA). They function by specifically targeting and blocking the activity of proteins that play a critical role in the inflammation process. While biologics are not a cure for RA, they have the potential to slow the disease’s progression.
Biologics work by zeroing in on specific parts of the inflammatory pathway. Each biologic drug is designed to target a different molecule within this process. Standard RA medications, such as DMARDs, aim to stop or lessen inflammation. DMARDs that treat RA include drugs like Plaquenil (hydroxychloroquine), Arava (leflunomide), and Otrexup (methotrexate).
These biologics are a subset of DMARDs. Unlike conventional or nonbiologic DMARDs, such as methotrexate—which are small molecules synthesized chemically in a lab—biologics are derived from living cells. Some drugs within this class are formulated to treat rheumatoid arthritis, while others may be more effective for conditions like psoriatic arthritis.
Biological response modifiers represent a newer class of drugs specifically designed to treat rheumatoid arthritis. These advanced biologics have vastly improved the treatment for many individuals with RA. Unlike older disease-modifying treatments, biologics directly target the immune system components that contribute to the inflammation and joint damage characteristic of RA.
Diagnosing rheumatoid arthritis can be challenging, especially in its early stages, as initial signs and symptoms often resemble those of many other conditions. There is no single blood test or physical finding that can conclusively diagnose RA. Biologic agents, also known as biologic response modifiers, are part of this newer class of DMARDs and include medications like abatacept (Orencia).
In the context of RA, inflammation typically affects the small joints, leading to pain and swelling, which eventually results in progressive joint destruction. This not only reduces the quality of life for affected individuals but also impairs physical function. Treating RA with biologics can significantly mitigate these effects and improve overall patient outcomes.
For further detailed information on biologics for Rheumatoid Arthritis, please visit the following links:
WebMD
Everything to Know About Biologics for Rheumatoid Arthritis
Benefits and Types of Biologics for RA
Arthritis Foundation
Healthline
Mayo Clinic
Treatment with Biologicals in Rheumatoid Arthritis: An Overview
